- Tightening Ligaments: The injections are strategically placed in weakened ligaments around the spine. Common sites include the supraspinous, interspinous, iliolumbar, and posterior longitudinal ligaments, which are crucial for maintaining spinal stability. By injecting these ligaments with a proliferant solution, prolotherapy induces a controlled inflammatory response. The body responds by laying down new collagen fibers, which strengthens and tightens the ligaments. Over time, this tightening effect reduces ligament laxity, providing more stability to the spinal segments. Clinical studies have shown that prolotherapy can effectively strengthen spinal ligaments and enhance spinal stability.
- Realigning Spinal Segments: With improved ligament strength and tension, the spine becomes more stable. This stabilization allows for gradual realignment of the vertebral segments. As ligaments become stronger, they can better hold the vertebrae in their proper anatomical position, reducing the degree of spondylolisthesis. Case studies and pilot studies have indicated improvements in spinal alignment and reductions in vertebral slippage following prolotherapy treatment.
- Pain Reduction and Improved Functionality: As prolotherapy addresses the underlying cause of pain—spinal instability and ligament laxity—patients often experience significant pain relief. This relief occurs because tightened ligaments reduce the abnormal motion of the vertebrae, decreasing irritation and compression of the spinal nerves. Consequently, patients often report improved mobility, function, and quality of life. A systematic review of prolotherapy for various chronic musculoskeletal conditions has reported consistent pain reduction and functional improvements.
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